Metabolism and distribution of 3,4-epithiobutanenitrile in the rat |
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Authors: | E.R. Brocker M.H. Benn J. Lüthy A. von Däniken |
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Affiliation: | Department of Chemistry, The University, Calgary, Alberta, Canada T2N 1N4;Institut für Toxikologie der ETH und der Universität Zürich, Schorenstrasse 16, CH-8603 Schwerzenbach, Switzerland |
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Abstract: | The metabolism and distribution of [2-14C]- and 35S-labelled 3,4-epithiobutanenitrile (4ETN), a thiirane occurring naturally in cruciferous vegetables, was studied in the rat. A dose of c. 11 mg 4ETN/kg body weight was rapidly transformed into water-soluble compounds and was mainly excreted in the urine, irrespective of the route of administration (oral or ip). The main metabolite in the urine was identified by gas chromatography-mass spectrometry as a mercapturic acid derivative. Low residual radioactivity demonstrated in organs 72 hr after administration was consistent with an earlier report that the thiirane may function as a weak biological alkylating agent. |
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Keywords: | 4ETN 3,4-Epithiobutanenitrile GC gas chromatography MS mass spectrometry NMR nuclear magnetic resonance TLC thin-layer chromatography |
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