规律吸入噻托溴铵对慢性阻塞性肺疾病稳定期患者的长期疗效

噻托溴铵是一种长效的吸入型支气管扩张剂,通过选择性地拮抗M3受体发挥作用,吸入一次,疗效可维持24 h以上.目前已有的临床证据表明,规律使用该药对中、重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)具有良好疗效,除了改善肺功能参数外,它在改善呼吸困难、生活质量、减少急性加重次数和住院次数方面要优于安慰剂、异丙托溴胺和长效β2受体激动剂.本品用药方便,安全性好,可作为一线和基础药物长期用于稳定期COPD患者.噻托溴铵的远期疗效及其与其他药物联合治疗的作用还有待进一步研究.

Long-term therapeutic effect of regular inhalation of tiotropium bromide on stable phase chronic obstructive pulmonary disease patients

Tiotropium bromide is a kind of long acting bronchodilators by inhalation which can selectively rival M3 receptor.A single dose of tiotropium bromide can maintain therapeutic effect more than 24 hours.Clinical evidence confirmed that regular application of tiotropium bromide had good curative effect on moderate-to-severe chronic obstructive pulmonary disease(COPD).Apart from ameliorating pulmonary function parameters,tiotropium bromide could also ease dyspnea,improve life quality,reduce the times of acute exacerbation and hospitalization,whose therapeutic effect outweigh placebo,ipratropium and long-term β2 receptor agonist.Tiotropium bromide is convenient and safe to apply,which is suitable for long-term therapy to stable phase COPD patients as a basic medicine.The prostective efficacy of tiotropium bromide and its therapeutic alliance with other medicine are still left to investigate.