鼻一氧化氮检测在儿童过敏性鼻炎中的临床意义

目的：了解鼻一氧化氮（nNO）检测对儿童过敏性鼻炎（AR）诊断和管理的价值。方法：选择30例经症状和过敏原特异性IgE检测确诊的AR患儿设为AR组，13例有过敏性鼻炎症状以及过敏史或过敏家族史的患儿设为可疑过敏性鼻炎（SAR）组；12例无鼻部症状、无过敏性疾病家族史的健康儿童设为正常组。使用Sunvou呼出气NO测定系统，应用鼻被动呼气+静音技术检测各组nNO水平。AR组给予鼻用激素丙酸氟替卡松鼻喷剂治疗2周后评估疗效，复查nNO，比较各组间、AR组治疗前后nNO水平。结果：三组患儿性别、年龄比较差异均无统计学意义（P均>0.05）。AR组、SAR组、正常组的nNO水平分别为（842±133）ppb、（569±44）ppb、（289±33）ppb，AR组和SAR组均高于正常组（P均<0.05）。12例（40%）AR患儿经丙酸氟替卡松鼻喷剂治疗后症状改善，治疗后nNO水平低于治疗前（P<0.05）。结论：nNO检测对AR的诊断、随访有一定的临床价值，nNO辅助诊断AR需要综合考虑鼻炎和鼻窦口通畅情况。

Clinical Significance of Detection of Nasal Nitric Oxide in Children with Allergic Rhinitis

Objective: To investigate value of nasal nitric oxide (nNO) as a biomarker in diagnosis and management of children with allergic rhinitis (AR). Methods: Thirty children diagnosed with symptoms and allergen-specific IgE detection were extracted as the AR group, 13 children with allergic rhinitis symptoms and allergic history or allergic family history were recruited as the suspected AR (SAR) group, and 12 healthy children without nasal symptoms and allergic family history were recruited as the normal group. The Sunvou exhaled NO measurement system was adopted, the nasal passive exhalation + mute technology were used to detect the nNO level of each group. The AR group was treated with fluticasone propionate nasal spray for two weeks, and the efficacy was evaluated, the levels of nNO were detected. The levels of nNO were compared among three groups, as well as before and after treatment in the AR group. Results: There was no statistically significant difference in age and gender among three groups (P>0.05). The levels of nNO of the AR group, the SAR group and the normal group were respectively (842±133) ppb, (569±44) ppb, and (289±33) ppb, and the levels nNO of the AR group and the SAR group were higher than those of the normal group (P<0.05). The symptoms of 12 cases in the AR group were improved after treatment with fluticasone propionate nasal spray, and the levels of nNO after treatment were lower than those before treatment (P<0.05). Conclusion: nNO detection has certain clinical value for the diagnosis and follow-up of AR, and the auxiliary diagnosis of AR requires comprehensive consideration of the condition of rhinitis and paranasal sinuses.