UDP-glucuronosyltransferase genetic variation in North African populations: a comparison with African and European data |
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| Authors: | Apolonia Novillo María Gaibar Alicia Romero-Lorca Hassen Chaabani Nadir Amir Pedro Moral |
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| Institution: | 1. Basic Biomedical Sciences Department, Universidad Europea de Madrid, Madrid, Spain;2. Faculty of Pharmacy, University of Monastir, Monastir, Tunisia;3. Laboratoire de Biochimie Appliquée, 5 Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, Algeria;4. Section of Zoology and Biological Anthropology, Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain;5. Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain |
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| Abstract: | Background: Genetic variation in glucuronosyltransferases (UGT) is crucial in drug metabolism and risk of some diseases.Aim: To examine genetic variation in UGT in North African populations.Subjects and methods: Allele frequencies of SNPs UGT1A424Thr, UGT1A448Val, UGT2B1585Tyr, UGT2B15523Thr and UGT2B17 CNV deletion from Morocco, Algeria, Tunisia and Libya were compared to European and Sub-Saharan populations.Results: North Africans are the group with the highest genetic heterogeneity given by internal differences in the occurrence of UGT2B17 deletion, UGT1A448Val and UGT1A4 haplotypes. UGT2B15 SNPs differentiate Sub-Saharans from the rest of the populations.Conclusion: North African populations show a high frequency of carriers of UGT2B15523Thr, a variant linked to an increased risk of prostate cancer. High Atlas Moroccans and Algerians show low frequency of UGT2B17del, a variant associated with high concentrations of testosterone and oestradiol. |
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| Keywords: | Glucuronidase UGTs pharmacogenetics genetic diversity risk-associated alleles |
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