Polyunsaturated phosphatidylcholine micelle-induced decrease of atherogenicity of the serumin vitro

It is shown that polyunsaturated phosphatidylcholine administered in micelles stabilized by a plant-derived glycoside prevents the accumulation of cholesterol by cells incubated in atherogenic serum and, moreover, in certain cases causes a 1.4–1.5-fold drop of intracellular cholesterol as compared to control cells. The optimum antiatherogenic effect was achieved when using a micelle concentration of 100–200 μg/ml and an incubation time of at least 4 hours. The antiatherogenic effect was analogous to the effect of high density serum lipoproteins. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 5 pp. 497–501, May, 1995 Presented by Yu. M. Lopukhin, Member of the Russian Academy of Medical Sciences