| 宫内发育迟缓大鼠不同阶段胰岛功能及胰岛素敏感性的研究 |
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| 引用本文： | 陈璐,刘翠萍,徐宽枫,茅晓东,袁庆新,刘超. 宫内发育迟缓大鼠不同阶段胰岛功能及胰岛素敏感性的研究[J]. 中华内分泌代谢杂志, 2009, 25(1). DOI: 10.3760/cma.j.issn.1000-6699.2009.01.026 |
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| 作者姓名： | 陈璐 刘翠萍 徐宽枫 茅晓东 袁庆新 刘超 |
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| 作者单位： | 1. 江苏省常州市第一人民医院内分泌科
2. 南京医科大学第一附属医院内分泌科,210029 |
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| 基金项目： | 江苏省医学重点学科资助项目 |
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| 摘 要： | 采用营养不良法建立官内发育迟缓(intrauterine growth retardation,IUGR)大鼠模型,发现IUGR大鼠胰腺发育受损、胰岛β细胞功能减退,随年龄增长逐渐出现糖耐量受损及胰岛素敏感性下降.
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| 关 键 词： | 宫内发育迟缓 糖尿病,2型 胰岛β细胞功能 胰岛素敏感性 |
Study on pancreatic islet β-cell function and insulin sensitivity at different stages of lifetime in rats born with intrauterine growth retardation |
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| CHEN Lu,LIU Cui-ping,XU Kuan-feng,MAO Xiao-dong,YUAN Qing-xin,LIU Chao. Study on pancreatic islet β-cell function and insulin sensitivity at different stages of lifetime in rats born with intrauterine growth retardation[J]. Chinese Journal of Endocrinology and Metabolism, 2009, 25(1). DOI: 10.3760/cma.j.issn.1000-6699.2009.01.026 |
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| Authors: | CHEN Lu LIU Cui-ping XU Kuan-feng MAO Xiao-dong YUAN Qing-xin LIU Chao |
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| Abstract: | The intrauterine growth retardation (IUGR) model was established by maternal nutrition restriction during mid- to late-gestation. IUGR rats had both impaired pancreatic development and islet β-cell dysfunction. As the animals grew, the rats gradually showed impaired glucose tolerance and decreased insulin sensitivity. |
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| Keywords: | Intrauterine growth retardation Diabetes mellitus,type 2 Islet β-cell function Insulin sensitivity |
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