Performance characteristics of updated INNO-LiPA assays for molecular typing of human leukocyte antigen A (HLA-A), HLA-B, and HLA-DQB1 alleles |
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| Authors: | De Vreese Karen Barylski Rachel Pughe Fiona Bläser Miriam Evans Colin Norton John Semana Gilbert Holman Richard Loiseau Pascale Masson Dominique Gielis Mieke De Brauwer Annelies De Canck Ilse Verpooten Gonda Hulstaert Frank |
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| Affiliation: | Innogenetics N.V., B-9052 Ghent, Belgium. Karen_De_Vreese@innogenetics.be |
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| Abstract: | We carried out a multicenter performance evaluation of three new DNA-based human leukocyte antigen (HLA) typing assays: INNO-LiPA HLA-A Update, INNO-LiPA HLA-B Update, and INNO-LiPA HLA-DQB1 Update. After optimization, the accuracy rates were all 100%, and the final observed resolutions were 99.4, 92.4, and 85.6%, respectively. These rapid and easy-to-perform assays yielded results fully concordant with other DNA-based tissue typing tests. |
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