血尿酸水平与2型糖尿病肾病发生发展的关系

目的:探讨2型糖尿病患者血尿酸水平与糖尿病肾病发生发展的关系。方法:选择上海市黄浦区中心医院收治的2型糖尿病患者151例,根据尿白蛋白和肌酐比值(ACR)分为单纯糖尿病组(SDM组)、早期糖尿病肾病组(EDN组)、临床糖尿病肾病组(CDN组),另选50例健康体检者作为对照组(NC组),分别测定血尿酸(UA)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,计算体质量指数(BMI),进行相关统计学分析。结果:糖尿病组UA水平高于对照组(P<0.05),CDN组UA水平明显高于SDM组及EDN组(P<0.05)。多元逐步回归分析表明UA是ACR的主要影响因素(R2=0.4816,P<0.05)。结论:血尿酸水平是尿白蛋白和肌酐比值的主要影响因素,高尿酸血症可促进2型糖尿病肾病的发生和发展。

Relationship between the level of serum uric acid and the occurrence and development of type 2 diabetic nephropathy

Objective： To analyze the relationship between the level of serum uric acid and the occurrence and development of type 2 diabetic nephropathy. Methods： According to albumin to creatinine ratio（ACR） , 151 cases of type 2 diabetes were divided into simple diabetes mellitus group （ SDM）, early diabetic nephropathy group （ EDN ）, clinical diabetic nephropathy group （ CDN ）, and the other 50 healthy cases were choosed as normal control group （NC）. Serum uric acid （ UA）, total cholesterol （ TC ） , triglyceride （TG） low-density lipoprotein cholesterol（LDL-C） were , high-density lipoprotein cholesterol （ HDL-C）, detected respectively. Meanwhile, the body mass index（BMI） was calculated, and the statistical analysis was made. Results： The level of UA in all diabetes groups were higher than NC group. The level of UA in CDN group was obviously higher than SDM group and EDN group. The multiple stepwise regression analysis showed that UA was the main influence factor of ACR（R^2 = 0. 4816, P 〈 0.05 ）. Conclusion ： Serum uric acid was the main influence factor of ACR. Hyperuricemia can promote the happening and development of diabetic nephropathy.