国人Brugada综合征的临床特点(附49例报告)

为了解国人Brugada综合征(BrS)的临床特征,采用计算机和人工文献检索收集文献及本院的病例,由两位医师进行分析,剔除重复的、非国人的病例。共49例,男性45例,女性4例,19-73(42.9±13.2)岁。有临床症状40例,主要表现为猝死29例、晕厥27例;有猝死或晕厥家族史17例,14例发生恶性室性心律失常(MVA),发生率82.4％;无猝死或晕厥家族史32例,15例发生MVA,发生率为46.9％(P<0.05)。14例有MVA发生时间记录,其中11例发生时间段为7:00pm-7:00am;ECG显示V1、V2导联ST段以下斜型抬高为主,V3ST段以马鞍型抬高为主。提示国人中BrS并不少见,其特征与国外报告相似。

Clinical characteristics of Brugada syndrome in Chinese:A report of 49 cases

This paper is to study the clinical characteristics of Brugada syndrome (BrS) in Chinese by analyzing clinical and ECG data of BrS patients. Data were included by computerized and manual research, and was analyzed by 2 doctors alone. The data of repetition and of non-Chinese were rejected. Forty-nine BrS patients were included (45 males and 4 females). Main manifestations included sudden death in 29 and syncope in 27 patients. Malignant ventricular arrhythmia (MVA) occurred in 14 of 17 patients with family history of sudden death or syncope and in 15 out of 32 ones without family history. Occurrence of MVA in 11 of 14 patients was within the period from 7pm to 7am. ECG revealed that sloped ST segment elevation appeared mainly in V1, V2 leads and coved ST segment elevation appeared mainly in V3 lead. BrS is not rare in Chinese people,and its clinical characteristics is similar to that overseas data.