| 抑癌基因PTEN在结直肠癌组织中的表达及临床意义 |
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| 引用本文： | 任辉,姜涛,李颖,张广,田宇,王巍. 抑癌基因PTEN在结直肠癌组织中的表达及临床意义[J]. 中国实验诊断学, 2005, 9(1): 122-123 |
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| 作者姓名： | 任辉 姜涛 李颖 张广 田宇 王巍 |
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| 作者单位： | 1. 吉林大学中日联谊医院,吉林,长春,130033
2. 吉林大学基础医学院,电子教研室 |
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| 摘 要： | 目的 探讨抑癌基因PTEN在结直肠癌发生、发展中的作用及其与临床病理特征的相关性。方法 采用免疫组织化学链霉菌抗生物素蛋白 过氧化酶法 (S P法 ) ,检测 6 0例结直肠癌组织中PTEN蛋白表达。结果 结直肠癌组织中 ,PTEN蛋白表达阳性率为 2 5 0 0 % (15 /6 0 ) ,与肿瘤分化程度呈正相关 (r =0 86 9,P <0 0 5 ) ,与TNM分期、淋巴结转移和肝转移呈负相关 (r=- 0 791,r=- 0 74 1,r=- 0 6 34,P <0 0 5 )。结论 抑癌基因PTEN参与结直肠癌的发生发展过程 ;PTEN基因与结直肠癌临床病理特征具有明显相关性 ,有望成为结直肠癌的诊断和预后判断的标记物。
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| 关 键 词： | 结直肠癌 抑癌基因PTEN 免疫组织化学 |
| 文章编号： | 1007-4287(2005)01-0122-02 |
| 修稿时间： | 2004-05-26 |
The clinical significance of PTEN protein expression in colorectal carcinoma |
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| REN Hui,JIANG Tao,ZHANG Guang,et al.. The clinical significance of PTEN protein expression in colorectal carcinoma[J]. Chinese Journal of Laboratory Diagnosis, 2005, 9(1): 122-123 |
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| Authors: | REN Hui JIANG Tao ZHANG Guang et al. |
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| Abstract: | Objective To investigate the correlation between the expression of tumour suppressor gene PTEN and clinicalpathological features in colorectal carcinoma. Methods The expression of PTEN protein in normal colorectal mucosa and colorectal carcinoma was observed by S P immunohistochemical assay. Results The positive expression rate of PTEN protein was 25 00%(15/60). PTEN protein expression was positively correlated with pathological differentiational degree( r =0 869, P <0 05), negatively with TNM staging, lymph nodes metastasis and hepatic metastasis( r =-0 791, r =-0 741, r =-0 634, P <0 05). Conclusion PTEN played a pivotal role in progression of colorectal carcinoma. The expression of PTEN is closely related to clinicopathological features in colorectal carcinoma, and could be used as marker of tumour burden of colorectal carcinoma. |
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| Keywords: | Colorectal carcinoma Anti-oncogene PTEN Immunohistochemistry |
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