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Design and Simulation of Active Biochip System

Authors:	Wenwei?Zhu,Wenbiao?Zhu,Wenhong?Zhang,Fengchan?Han,Xiuzhen?Dong,Xiaojun?Yan author-information" > author-information__contact u-icon-before" > mailto:xiaojuny@fmmu.edu.cn" title=" xiaojuny@fmmu.edu.cn" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Institute of Genetic Diagnosis, The Fourth Military Medical University, Xian, 710032, P.R. China;(2) Department of Bio-Medical Engineering, The Fourth Military Medical University, Xian, 710032, P.R. China;(3) Beijing System Design Institute of Electro-Mechanic Engineering, Beijing, 100854, P.R. China;(4) State Key Laboratory of Cancer Biology, Xian, 710032, P.R. China

Abstract:	To solve the problems existing in passive biochip systems, we designed a novel active biochip system. This system introduces negative pressure and controlling devices to adjust the antigen-antibody reaction on the nitrocellulose membrane. Computational simulation demonstrated that this system is a rapid, stable, robust and practical system that may enhance the efficiency of antigen-antibody reactions and improve the repeatability and accuracy of biochip analysis.

Keywords:	active biochip protein chip immunoreactions pressure control
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