Castleman病并发霍奇金淋巴瘤1例报道及文献复习

目的探讨Castleman病（Castlemans disease,CD）并发霍奇金淋巴瘤（Hodgkin′s lymphoma,HL）的诊断要点与发病机制。方法应用病理组织学、免疫组化技术对1例CD并发HL进行分析。结果CD具有弥漫性多细胞成分的背景中有散在胸腺小体样生发中心和双核、单核、多核及嗜酸性大核仁的R-S细胞（CD30与CD15膜点阳性）。本例与文献报道共23例CD并发HL病例中,浆细胞型CD占73.9%（17/23）。HL中滤泡间HL 12例,NSHL6例,两者占78.3%（18/23）。结论CD并发HL病例多发于CD浆细胞型、滤泡间与NSHL,其发病机制可能与CD生发中心B细胞、HL的R-S细胞及组织细胞产生IL-6以及患者免疫机能异常有关。

Castleman's disease coexisted with Hodgkin's lymphoma: A case report and review the literatures

Purpose To explore the major diagnostic points and the pathogenetic mechanisms of Castleman's disease(CD) Hodgkin's lymphoma(HL).Methods The morphopathologic characteristics of 1 case CD with HL were studied by using histopathological,immunohistochemical techology.Results The histopathology of the case showed that there was a background of multiple cells and scattered thymus gland body-like germinal centers and R-S cells of one or two and multiple nuclei with eosinophilic large nucleolus(CD 30 and CD 15 positive).The case and other 22 cases in literatures were reported till now.There were plasma cell type CD in 73.9%(17/23) and 12 cases of interfollicular HL and 6 NSHL accounted for 78.3%(18/23) of all cases of HL.Conclusions The CD co-existed with HL preferentially occurs in plasma cell type CD and interfollicular HL and NSHL.The pathogenetic mechanisms were possibly associated with secretion of interlukin-6 by R-S cells,histiocyte and B cells in germinal center of CD and abnormal immune status in the patients.