| 软骨细胞—支架复合的修复兔耳廓软骨缺损 |
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| 引用本文： | 刘彦春,王炜.软骨细胞—支架复合的修复兔耳廓软骨缺损[J].中华整形烧伤外科杂志,1999,15(3):180-182. |
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| 作者姓名： | 刘彦春 王炜 |
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| 摘 要： | 目的 在有免疫力的动物兔体内探索组织工程化软骨对软骨缺损的修复能力。方法 软骨细胞种于经不同物质修饰的聚羟基乙酸支架体外培养后修复兔耳廓软骨缺损，与对照组比较，并从大体及组织学进行评价。结果 软骨细胞种于经不同物质修饰的聚羟基乙酸支架体外培养后回植到兔耳廓软骨缺损部位，软骨缺损得到修复，但人骨交上为纤维组织。注射软骨细胞悬液、以聚羟基乙酸支架修复及空白对照组软骨缺损均未修复。结论 软骨细胞种于经不
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| 关 键 词： | 聚羟基乙酸 软骨细胞 修复 耳廓软骨缺损 |
Repair of rabbit auricular defects using chondrocyte-scaffolding constructs] |
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| Authors: | Y Liu W Wang Y Cao |
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| Institution: | Department of Plastic Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University, Shanghai 200011. |
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| Abstract: | OBJECTIVE: To evaluate if the tissue-engineered cartilage can repair the auricular defects in rabbits that have inherent immunity. METHODS: Rabbit auricular defects were repaired using chondrocyte-PGA constructs cultured in vitro. The gross and histological comparisons were made between the experimental and the control groups. RESULTS: The rabbit auricular defects were repaired with chondrocyte-PGA constructs, leaving fibroid tissue in the interface between the tissue-engineered cartilage and the normal cartilage. CONCLUSION: The auricular defects can be repaired by chondrocyte-PGA in vitro cultured constructs in animals like rabbits that have acquired immunity. The interface healing problems need further study. |
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