| 白细胞介素—1对病理性瘢痕成纤维细胞胶原合成的影响 |
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| 引用本文： | 杨东元 罗锦辉. 白细胞介素—1对病理性瘢痕成纤维细胞胶原合成的影响[J]. 中华整形烧伤外科杂志, 1999, 15(6): 434-436 |
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| 作者姓名： | 杨东元 罗锦辉 |
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| 摘 要： | 目的 探讨细胞因子对瘢痕成纤维细胞生物学活性的调控。方法 以病理性瘢痕成纤维细胞为研究对象，观察白细胞介素－１（以下简称ＩＬ－１）对共胶原合成、核酸、超微结构的影响。结果 ＩＬ－１可以抑制病理性瘢痕成纤维细胞胶原合成及枋酸的量。结论 ＩＬ－１是瘢痕调控机制中的负性调节因子，在病理性瘢痕的防治中有一定的应用价值。
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| 关 键 词： | 白细胞介素－1 瘢痕 成纤维细胞 胶原合成 |
The effects of IL-1 on synthesis of collagen in scar-derived fibroblasts] |
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| D Yang,J Luo,J Zhu. The effects of IL-1 on synthesis of collagen in scar-derived fibroblasts][J]. , 1999, 15(6): 434-436 |
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| Authors: | D Yang J Luo J Zhu |
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| Affiliation: | Department of Plastic Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515. |
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| Abstract: | OBJECTIVE: To investigate modulation of cytokines on biological activities of scar-derived fibroblasts. METHODS: This study focused on the effects of interleukin-1 (IL-1) on collagen biosynthesis, nucleic acid, and cell organs of fibroblasts. RESULTS: The results showed the IL-1 could reduce not only the collagen synthesis of fibroblasts, but also quantity of nucleic acid. CONCLUSION: The authors confirm that IL-1 is a cytokine with down-regulation effect on scar formation, and suggest that IL-1 can play an important role in prevention and treatment of scar. |
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