一氧化氮对烧伤大鼠血小板功能的影响

目的 探讨一氧化氮（ＮＯ）对烧伤大鼠血小板粘附和聚集功能的影响。方法 采用３０％ＴＢＳＡⅢ度烧伤大鼠模型，将１０４只Ｗｉｓｔａｒ大鼠随机分为烧伤对对照（Ｂ）、ＮＯ供体（Ｓｉｎ－１）、ＮＯ阻断剂（Ｌ－ＮＡＭＥ）及正常对照（Ｃ）４组，分别于伤前及伤后３，６，１２，２４ｈ测定血小板１ｍｉｎ聚集率、最大聚集率、解聚率及粘附率。结果 烧伤后各组大鼠血小板１ｍｉｎ聚集率、最大聚集率及粘附率均明显高于伤前，而解

Effects of nitric oxide on platelet function in burned rats]

OBJECTIVE: To investigate the effects of nitric oxide (NO) on rat platelet function after burn injury. METHODS: Wistar rats with 30% TBSA full thickness burns were used as model, indices of platelet functions including platelet aggregation rate in first minute (PAR-1), maximal platelet aggregation rate (PAR-m), platelet dissipation rate (PDR) and platelet adhesion rate (PAR) were determined in four groups, namely burn control (B), NO donor (sin-1), NO synthesis inhibitor (L-NAME) and the normal control (C). RESULTS: The PAR-1, PAR-m and PAR were significantly increased and the PDR was decreased remarkably after burn injury. In sin-1 group the PAR-1, PAR-m and PAR were obviously lower and the PDR was higher than that of B group (P < 0.05-0.01). In L-NAME group the PAR-1 was higher and the PDR was lower as compared with B group, but the PAR-m and PAR showed no significant differences between two groups. CONCLUSIONS: The ability of platelet adhesion and aggregation induced by activated platelet are increased after burn injury. NO can partially reduce the degree of platelet activation and inhibit platelet aggregation. Moreover, it may dissipate aggregated platelets.