细胞凋亡抑制基因bcl—2在血管瘤发病中作用的研究

目的 阐明细胞凋亡抑制基因Ｂ细胞淋巴瘤／白血病－２基因（ｂｃｌ－２）与血管瘤的关系。方法 用免疫组化ＳＰ法检测３８例篾这瘤及６例正常皮肤组织中ｂｃｌ－２的表达。结果 ｂｃｌ－２在海绵状及蔓状血管瘤中表达高于正常；毛细知管瘤中表达低于正常；其间的差异有统计学意义。结论 从以上结果可以认为：海绵状及蔓状血管瘤增生与ｂｃｌ－２表达增高有关；而ｂｃｌ－２在毛细血管瘤中表达低说明其存在自然消退的可能。

The study on the role of apoptosis suppressive gene bcl-2 in the pathogenesis of hemangioma]

OBJECTIVE: To elucidate the relationship between bcl-2 and hemangioma. METHODS: We investigated the expression of bcl-2 in 38 samples of hemangioma (19 cases of capillary hemangioma, 10 cases of cavernous hemangioma, 9 cases of racemose hemangioma) and 6 samples of normal skin by immunohistochemical SP method. RESULTS: The results showed that the expression of bcl-2 was higher in cavernous and racemose hemangioma than in the controls, the expression of bcl-2 was lower in capillary hemangioma than in the controls. The differences were statistically significant. CONCLUSION: It can be deduced from the results that there is an intimate relationship between bcl-2 and the growth of cavernous and racemose hemangioma, and the lower expression of bcl-2 in capillary hemangioma shows that capillary hemangioma may disappear naturally.