间甲酚化学烧伤实验性治疗

目的 开展间甲酚化学烧伤动物实验研究，为临床治疗提供理论依据。方法 将间甲酚原液涂在家兔背部，并随机分为对照、手术切痂、ＳＤ－Ａｇ涂药、饱和硫酸钠湿敷及自来水冲洗组。检测血液中ＢＵＮ、ＡＬＴ、ＡＳＴ、ＧＧＴ、ＡＫＰ５种生化指标。观察心、肝、脑、肺、肾的病理变化及超微结构变化。结果 间甲酚不仅可对皮肤造成深度烧伤，而且经过皮肤渗透还可引起全身主要脏器的４种不同治疗方法均有效，其中以手术切痂、外涂ＳＤ

An experimental study of metacresol burn]

OBJECTIVE: To study the characteristics of metacresol burn. METHODS: Metacresol of 99.6% was used. The animals were randomly separated into control group, excision group, topical SD-Ag group, saturated sodium sulfate wet compress group, and warm running water flushing group. RESULTS: It was proved that metacresol could not only cause deep burns to skin but also penetrate skin and to produce impairment of functions of the main internal organs of the body, as shown by abnormalities in blood BUN, GPT, GOT, GGT, and AKP. Pathological changes were also found in the liver, heart, brain, kidney, and skin with light and electron microscopy. CONCLUSION: Through comparison of the four different treatment methods for metacresol burns, it is concluded that excision of the wound followed by skin grafting should be done as early as possible to minimize absorption of the chemical. Topical application of SD-Ag or sodium sulfate wet compress, and flushing with running water can alleviate direct injury to skin. Drugs to protect the heart, liver, and kidney should be used for a longer period than usual.