皮肤软组织扩张中自由基水平的实验研究

目的 探讨组织扩张过程中自由基的生成及其对组织扩张的影响。方法 ＳＤ大白背部置入２０ｍｌ圆形扩张器，常规扩张２３￣２５天，于最后一次扩张前、扩张后１，６，１２和２４ｈ分别测定扩张皮肤组织中ＳＯＤ活性和ＭＤＡ含量；同时观察自由基清除剂ＳＯＤ对扩张面积、长度的影响。结果 ＳＯＤ活性和ＭＤＡ含量扩张后１，６及１２ｈ与扩张前比较差异有非常显著意义，至扩张后２４ｈ基本回复到扩张前水平；ＳＯＤ治疗组扩张面积、

Preliminary experimental study on free radicals in expanded soft tissue]

OBJECTIVE: To inquire into the formation of free radicals during tissue expansion and its influence on tissue expansion. METHOD: Expanders of 20 ml were placed beneath the dorsal skin of SD rats, and the conventional expansion course took about 23 to 25 days. The activity of SOD and the content of MDA in skin were determined prior to the last expansion, 1 h, 6 h, 12 h and 24 h after the last expansion, respectively. Meanwhile, the effect of SOD on expansion area and length was observed. RESULT: The activity of SOD and the content of MDA at 1 h, 6 h, and 12 h after expansion were significantly different from those before expansion, while the activity of SOD and the content of MDA at 24 h after expansion were almost the same as those before expansion. The difference of expansion area and length between SOD and NS groups was significant, especially during 16 to 24 days. CONCLUSION: Tissue expansion produces free radicals and SOD can increase expansion area and length. The study provides a clue to find a way for safe, rapid and effective soft tissue expansion.