膜内成骨与软骨成骨贴敷移植的早期血管化比较研究

目的 采用Ｗｉｓｔａｒ大鼠对颅骨（膜内成骨）和髂骨（软骨成骨）贴敷移植后早期再血管化进行了观察研究。方法 用计算机图像处理进行定量分析。结果 骨移植７天后，软骨 与膜内成骨血管密度分别为：２２．３３％和１１．８８％；１４天时分别为３４．９３％和１５．９３％。结论 软骨成骨移植后较膜内成骨有更加的血管化。文中地骨移植后骨质结构，血管化以及骨质体积存留之间的关系进行了讨论。

Comparative study on early revascularization of membranous and endochondral onlay bone grafts in the rat]

OBJECTIVE: To investigate the disparity in early revascularization of the membranous and endochondral bone grafts. METHODS: Twenty Wistar rats were randomly divided into two groups of 10 each. Full-thickness cranial (membranous) and split-thickness iliac crest (endochondral) onlay bone grafts were placed subperiosteally onto the snout of the animal without bony fixation. At 7 and 14 days after grafting the bone grafts together with the recipient sites were harvested. Revascularization was studied utilizing opacifying injection and computerized image analysis technique. RESULTS: The extent of vascularization at 7 days was 11.88% and 22.33% in membranous and endochondral bone grafts, respectively, and they developed to be 15.93% and 34.93% at 14 days, respectively. CONCLUSION: The results indicated that endochondral bone grafts were more rapidly revascularized than membranous bone grafts at 7 and 14 days (P < 0.05). Differences in graft architecture are theorized to account for the relationship between the vascularization and volume maintenance in the bones of different embryonic origin.