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Hepatocellular Carcinoma with Splenic Metastasis Developing after 16 Years of Chemotherapy for Chronic Myelogenous Leukemia: A Case Report |
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| Authors: | Katoh, Masaru Takeuchi, Kazuo Murashima, Naoya Nakajima, Masao Yamaguchi, Hisomu Endo, Yuzo Hara, Mitsuru |
| Affiliation: | 1 Department of Gastroenterology, Toranomon Hospital Tokyo 2 Department of Hematology, Toranomon Hospital Tokyo 3 Department of Pathology, Toranomon Hospital Tokyo |
| Abstract: | A case of hepatocellular carcinoma (HCC), which developed duringchemotherapy for chronic myelogenous leukemia (CML), is presented.A 55-year-old Japanese man, who had received an alkylating agentfor 16 years, was diagnosed as having HCC with clinically evidentsplenic metastases. The patient died of the HCC rupture threemonths after diagnosis. The autopsy revealed the HCC to havedeveloped from the non-cirrhotic liver. In the present case,DNA damage due to the long-term chemotherapy with the alkylatingagent for CML may have endowed the HCC induced by post-transfusionhepatitis and alcohol abuse with an aggressive proliferativepotential. This is the first report on HCC in association withCML. |
| Keywords: | Hepatocellular carcinoma Splenic metastasis Chronic myelogenous leukemia |
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