| 变应性鼻炎患者脱敏治疗前后白细胞介素-18水平变化 |
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| 引用本文： | 李文静,刘光辉,祝戎飞. 变应性鼻炎患者脱敏治疗前后白细胞介素-18水平变化[J]. 临床耳鼻咽喉头颈外科杂志, 2006, 20(5): 210-211 |
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| 作者姓名： | 李文静 刘光辉 祝戎飞 |
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| 作者单位： | 华中科技大学同济医院过敏反应科,武汉,430030;华中科技大学同济医院过敏反应科,武汉,430030;华中科技大学同济医院过敏反应科,武汉,430030 |
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| 摘 要： | 目的:探讨白细胞介素18(IL18)在变应性鼻炎(AR)的发病过程中的作用及脱敏治疗的作用机制。方法:以健康者作对照(对照组),用酶联免疫吸附方法检测AR患者(AR组)脱敏治疗(1年)前、后血清IL18水平。结果:AR组脱敏治疗前血清IL18水平(88.33±35.95)ng/L低于对照组(149±47.37)ng/L,2组比较差异有统计学意义(P<0.05)。而AR组脱敏治疗后血清IL18水平(199.22±58.82)ng/L明显升高,与对照组比较差异无统计学意义(P>0.05)。结论:IL18在AR组中低表达,而在脱敏治疗后表达增高,提示IL18在变应性炎症的发生、发展和脱敏治疗中起了重要作用。
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| 关 键 词： | 鼻炎 变应性 白细胞介素-1 免疫疗法 |
| 文章编号： | 1001-1781（2006）05-0210-02 |
| 收稿时间： | 2005-11-18 |
| 修稿时间： | 2005-11-18 |
The serum level transformation of interleukin 18 before and after SIT in patients with allergic rhinitis |
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| LI Wenjing,LIU Guanghui,ZHU Rongfei. The serum level transformation of interleukin 18 before and after SIT in patients with allergic rhinitis[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2006, 20(5): 210-211 |
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| Authors: | LI Wenjing LIU Guanghui ZHU Rongfei |
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| Affiliation: | Department of Allergy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China. |
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| Abstract: | OBJECTIVE: To survey the role of IL-18 in the pathogenesis of allergic rhinitis, and to discuss the mechanism of specific immunotherapy (SIT). METHOD: The serum levels of IL-18 in patients with allergic rhinitis and the health control were detected by ELISA before and after SIT (for lyear). RESULT: The levels of IL-18 in patients before SIT were (88.33 +/- 35. 95)ng/L, significantly lower than that in healthy control(149 +/- 47.37)ng/L, and the level after SIT (199.22 +/- 58.82 )ng/L was significantly higher than that before SIT. There was no significant difference between the healthy after-SIT. CONCLUSION: IL-18 plays an important role in the pathogenesis of allergic inflammation and the SIT therapy. |
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| Keywords: | Rhinitis, allergic Interleukin-18 Immunotherapy |
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