| 尼美舒利缓释片的研制和体外溶出度 |
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| 引用本文： | 郭曙刚,陈邦银,张汉萍. 尼美舒利缓释片的研制和体外溶出度[J]. 中国医院药学杂志, 2000, 20(7): 398-400 |
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| 作者姓名： | 郭曙刚 陈邦银 张汉萍 |
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| 作者单位： | 同济医科大学药学院,湖北,武汉,430030 |
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| 摘 要： | 目的：研究尼美舒利骨架缓释片的制备及体外释放特性。方法：采用卡波普、羧甲基纤维素钠等为骨架材料制备本品，通过溶出试验评价缓释效果。结果：本品在ｐＨ７．２缓冲液中可持续释药１２ｈ，释放规律符合零级动力学和Ｈｉｇｕｃｈｉ方程。结论：本品处方较合理，制备工艺较简单，体外试验具有明显的缓释效果。
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| 关 键 词： | 尼美舒利 缓释片 制备 体外溶出度 非甾体抗炎药 |
| 修稿时间： | 1999-03-05 |
The preparation and in vitro dissolution of nimesulide sustained-release tablets |
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| Guo Shugang,Chen Bangyin,Zhang Hanpin. The preparation and in vitro dissolution of nimesulide sustained-release tablets[J]. Chinese Journal of Hospital Pharmacy, 2000, 20(7): 398-400 |
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| Authors: | Guo Shugang Chen Bangyin Zhang Hanpin |
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| Affiliation: | Guo Shugang,Chen Bangyin,ZhangHanpin(Tongji Medical University Pharmacy Department,Wuhan 430030) |
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| Abstract: | OBJECTIVE:To study the preparation and in vitro releasing characterization of nimesulide sustained release tablets.METHODS:This tablet was prepared by carbopol CMC Na et al,the sustained release effect was appraised by dissolution test.RESULTS:It can be released continually in 12 hours in the pH 7.2 dissolution media,and the dissolution behavior fit zero order kinetic mechanism and Higuchi equation.CONCLUSIONS:This formulation is rational,technology is simple,release show sustaining. |
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| Keywords: | nimesulide sustdined release tablets preparation dissolution |
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