冠心病患者HSP70-2+1267A/G多态性与高敏C反应蛋白水平的相关性研究

冠心病（coronary artery disease，CAD）的病理基础是动脉粥样硬化，炎症是动脉粥样硬化的特征之一；研究发现炎症在冠状动脉粥样硬化斑块的发生、发展和粥样斑块的破裂过程中起重要作用，动脉粥样硬化被认为是一种慢性炎症的过程。热休克蛋白70-2（Hot Shock Protein，HSP）是HSP家族中重要的一员，

The Relationship between Heat-Shock Protein 70-2 Gene +1267A/G Polymorphism and Serum Level of High Sensitivity C-Reactive Protein in Patients with Coronary Artery Disease

Objective To explore the relationship between heat-shock protein 70-2 gene ＋1267A/G polymorphism（HSP70-2 gene ＋1267A/G polymorphism） and serum level of high sensitivity C-reactive protein（Hs-CRP） in patients with coronary artery disease（CAD）.Methods Serum Hs-CRP level and HSP70-2 gene ＋1267A/G polymorphism were detected in 185 patients with CAD.HSP70-2 gene ＋1267A/G polymorphism was screened by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）.Results The genotype distribution of the HSP70-2 gene ＋1267A/G polymorphism was as follows： AA was in 24 of 185 patients（12.97%）,AG in 93 of 185 patients（50.27%） and GG in 68 of 185 patients（36.76%）.Patients with GG、AG subtype had higher Hs-CRP levels compared with carriers of the AA subtype（4.5±1.8mg/L,3.2±1.2mg/L and 2.7±1.1mg/L,respectively,P〈0.05）.Among patients who had Hs-CRP 3mg/L,GG,and AG gene subtypes had higher percentage than A allele homozygotes（92.6%,74.2% and 45.8%,respectively.χ^2=17.75,28.04,P〈0.05）.Conclusions This study indicated G allele of HSP70-2 gene ＋1267A/G polymorphism may be an independent risk factor in systemic inflammation with stable CAD.