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| 先兆子痫患者HLA-DQA1、-DQB1、-DPA1基因多态性 | |
| 引用本文： | 侯磊,张曦,李大金,张展,贾莉婷,熊平,常彩虹,王雪梅,龚非力.先兆子痫患者HLA-DQA1、-DQB1、-DPA1基因多态性[J].中国免疫学杂志,2006,22(4):315-319. |
| 作者姓名： | 侯磊 张曦 李大金 张展 贾莉婷 熊平 常彩虹 王雪梅 龚非力 |
| 作者单位： | 1. 郑州大学第三附属医院,郑州,450050 2. 复旦大学附属妇产科研究所,上海,200011 3. 华中科技大学同济医学院免疫教研室,武汉,430030 |
| 摘 要： | 目的:探讨人类白细胞抗原HLA-DQ-A1、DQB1、DPA1基因多态性与先兆子痫发病的关系。方法:采用序列特异性引物技术(PCRSSP)对46例先兆子痫患者和105例正常孕妇及其新生儿进行HLA-DQ-DPA1等位基因分型。结果:所有标本共检出11种HLADQA1基因表型、16种HLADQB1基因表型、6种HLADPA1基因表型。先兆子痫患者HLA-DQ-B10301基因频率高于正常孕妇,差异有显著性(Pc=0.032,RR=2.43,AR=0.30),其余各基因表型频率两组比较差异均无显著性。结论:HLADQB10301基因可能是一种先兆子痫发病的易感基因。 |
| 关 键 词： | 妊娠并发症 先兆子痫 抗原 等位基因 多态性 |
| 文章编号： | 1000-484X(2006)04-0315-05 |
| 修稿时间： | 2005年5月20日 |
HLA-DQA1、-DQB1 and HLA-DPA1 Genotypes in preeclampsia |
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| HOU Lei,ZHANG Xi,LI Da-Jin,ZHANG Zhan,JIA Li-Ting,XIONG Ping,CHANG Cai-Hong,WANG Xue-Mei,GONG Fei-Li.HLA-DQA1、-DQB1 and HLA-DPA1 Genotypes in preeclampsia[J].Chinese Journal of Immunology,2006,22(4):315-319. | |
| Authors: | HOU Lei ZHANG Xi LI Da-Jin ZHANG Zhan JIA Li-Ting XIONG Ping CHANG Cai-Hong WANG Xue-Mei GONG Fei-Li |
| Abstract: | Objective:To clarify whether there are susceptible HLA-DQ or HLA-DPB1 alleles in women with preeclampsia.Methods:The HLA-DQ and HLA-DPA1 typing were performed using sequence-specific amplification(PCR-SSP)in 46 patients and 105 healthy pregnant women and their newborns.Results:The HLA-DQB1*0301 alleles frequency was higher in patients with preeclampsia(30.43%) than in the tested group of healthy controls(16.19%)(Pc=0.032,RR=2.43, AR=0.30), the HLA-DQA1 and HLA-DPB1 alleles frequency were no signficiant difference between two groups, so did newborns. No difference was found in HLA-DQ or HLA-DPB1maternal-fetal genetic sharing between them.Conclusion:Results suggest that the presence of HLA-DQB1*0301 alleles may increase the risk of preeclampsia. |
| Keywords: | Pregnant complication Preeclampsia HLA-DQ alleles HLA-DPA1 alleles Polymorphism |
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