P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis |
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| Authors: | Ming Chen Jian-Guo Geng |
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| Institution: | (1) Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, 200031, China;(2) Vascular Biology Center and Division of Hematology, Oncology and Transplantation, University of Minnesota Medical School, MMC 480, 420 Delaware Street S.E., Minneapolis, MN 55455, USA |
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| Abstract: | Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion
molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial
cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes
leukocytes intracellularly for cytokine and chemoattractant-induced β2-integrin activation for firm adhesion of leukocytes. Furthermore, P-selectin mediates heterotypic aggregation of activated
platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Here we provide a comprehensive summary
of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses
of inflammation, thrombosis, and the growth and metastasis of cancers. |
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| Keywords: | selectin cell adhesion molecule leukocytes platelets endothelial cells cancer cells inflammation thrombosis cancer growth and metastasis |
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