The behavioral actions of diazepam and oxazepam are similar |
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Authors: | S. P. Mewaldt M. M. Ghoneim J. V. Hinrichs |
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Affiliation: | (1) Department of Psychology, Marshall University, 25701 Huntington, WV, USA;(2) Department of Anesthesia, Department of Psychology, University of Iowa, Iowa City, IA, USA |
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Abstract: | In a double-blind and randomized study, we assessed the comparative pharmacodynamic profiles and behavioral effects of diazepam and oxazepam administered to young healthy volunteers. Diazepm 0.3 mg/kg or oxazepam 1.2 mg/kg or placebo were each administered orally to 13 subjects who were tested with tasks which measured learning and memory, cognition, psychomotor performance and mood before and for 9 h after treatment. The two drugs had similar actions, although subjective effects were milder after oxazepam, which also had a slower onset of action. There was no evidence of rebound behavioral impairment. |
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Keywords: | Diazepam Oxazepam Behavior Pharmacodynamic Learning Memory Cognition Psychomotor performance Mood |
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