| 由P-糖蛋白介导的药物相互作用研究进展 |
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| 引用本文： | 杨少林,李焕德,彭珍珍,赵绪元. 由P-糖蛋白介导的药物相互作用研究进展[J]. 中国医院用药评价与分析, 2011, 0(6): 494-497 |
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| 作者姓名： | 杨少林 李焕德 彭珍珍 赵绪元 |
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| 作者单位： | 中南大学湘雅二医院药剂科;中南大学药学院; |
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| 摘 要： | 目的:介绍由P-糖蛋白介导的药物相互作用研究进展。方法:以近几年国内、外有代表性的论文为依据,就P-糖蛋白性质、功能和作用机制在药物相互作用中的运用进行分析和评述。结果:发现P-糖蛋白可以介导抗肿瘤药、循环系统用药、抗生素类药、免疫调节剂、中枢神经系统用药等药物的相互作用。结论:由P-糖蛋白介导的药物相互作用研究不够深入,缺乏系统性研究。
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| 关 键 词： | P-糖蛋白 药物相互作用 研究进展 |
Research Progress on P-glycoprotein-mediated Drug Interactions |
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| YANG Shao-lin,,LI Huan-de,PENG Zhen-zhen,ZHAO Xu-yuan. Research Progress on P-glycoprotein-mediated Drug Interactions[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2011, 0(6): 494-497 |
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| Authors: | YANG Shao-lin LI Huan-de PENG Zhen-zhen ZHAO Xu-yuan |
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| Affiliation: | YANG Shao-lin1,2,LI Huan-de1,PENG Zhen-zhen1,ZHAO Xu-yuan1,2(1.Dept.of Pharmacy,The Second Xiangya Hospital of Central South University,Changsha 410011,China,2.School of Pharmacy,Central South University,Changsha 410013,China) |
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| Abstract: | OBJECTIVE:To introduce the research progress on P-glycoprotein-mediated drug interactions.METHODS:Based on recent representative papers both at home and abroad,the properties,functions and action mechanism of P-glycoprotein and their application in drug interaction was analyzed and reviewed.RESULTS:P-glycoprotein was found to be able to mediate drug interactions of such drugs as anti-tumor drugs,circulatory system drugs,antibiotics,immunomodulators and central nervous system drugs etc.CONCLUSION:There is la... |
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| Keywords: | P-glycoprotein Drug interaction Research progress |
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