国产缬沙坦与进口培垛普利治疗原发性高血压的药物经济学分析

目的:比较国产缬沙坦(缬克)与进口培哚普利(雅施达)治疗轻中度原发性高血压的临床疗效和费用。方法:70例轻、中度原发性高血压患者随机口服国产缬沙坦80 mg.d-1或进口培哚普利4 mg.d-1,4周末诊室坐位舒张压≥90 mmHg者剂量分别加倍至160 mg.d-1和8 mg.d-1,继续服用4周。结果:治疗前两组间各参数基线水平差异无统计学意义(P>0.05),8周末缬沙坦组和培哚普利组总有效率分别为79.4%和80.6%(P>0.05),缬沙坦组收缩压和舒张压分别下降23.4 mmHg和11.7 mmHg,培哚普利组收缩压和舒张压分别下降22.8 mmHg和12.1 mmHg,(P>0.05)。缬沙坦组和培哚普利组每月人均治疗费用分别为105元和124元。结论:国产缬沙坦与进口培哚普利治疗原发性高血压疗效没有差别,但国产缬沙坦成本更低,服药依从性及耐受性更好。

Domestic Valsartan vs. Imported Perindopril in the Treatment of Essential Hypertension:Pharmacoeconomic Analysis

OBJECTIVE： To evaluate the clinical efficacy and cost of domestic valsartan vs.imported perindopril（Acertil） for mild-to-moderate essential hypertension.METHODS： 70 patients with mild-to-moderate essential hypertension were randomized to receive either domestic valsartan（80 mg daily） or imported perindopril（4 mg daily） for a total of 8 weeks,however,doses were doubled to 160 mg daily vs.8 mg daily at the end of 4 weeks for patients with seated diastolic blood pressure ≥90 mmHg.RESULTS： No statistical significance was noted in the differences of baseline data between the two groups（P 〉 0.05）.At the end of 8 weeks,the total effective rate in patients receiving domestic valsartan was 79.4%,as compared with 80.6% in patients receiving imported perindopril（P 〉 0.05）;systolic blood pressure（SBP） and diastolic blood pressure（DBP） decreased by 23.4 mmHg and 11.7 mmHg,respectively in domestic valsartan group,as compared with a reduction of 22.8 mmHg and 12.1 mmHg in the imported perindopril group（P 〉 0.05）.The monthly average treatment cost per patient was 105 Yuan for patients receiving domestic valsartan,as compared with 124 Yuan for patients receiving imported perindopril.CONCLUSION： There were no differences in curative efficacy between the domestic valsartan and the imported perindopril in the treatment of essential hypertension,but domestic valsartan has lower cost and to which patients have better medication compliance and tolerability.