复方苦参注射液联合化疗治疗消化道肿瘤的疗效分析

目的观察复方苦参注射液联合化疗治疗消化道肿瘤患者的临床疗效分析。方法回顾性分析从2009年1月至2010年10月深圳市宝安区人民医院住院的晚期消化道恶性肿瘤患者,共137例,随机分为治疗组70例(复方苦参注射液加化疗方案)和对照组(单纯化疗)67例。化疗2~4个疗程,4周为1个疗程。比较两组患者的KPS评分、化疗不良反应及疼痛改善情况。结果治疗组患者的不良反应的发生率均低于对照组,差异具有显著性(P<0.05);治疗组KPS评分明显有效率及疼痛缓解率分别为74.29%、73.64%,高于对照组,具有显著性差异(P<0.05)。结论复方苦参注射液配合化疗,明显减轻化疗不良反应,提高患者生活质量,对消化道肿瘤患者具有较多获益,值得临床推广应用。

Clinical Efficacy of Compound Kushen Injection Combined with Chemotherapy for Advanced Digestive Neoplasm

Objective To evaluate the efficacy of compound Kushen injection combined with chemotherapy for advanced digestive neoplasm.Methods In this retrospective analysis,a total of 137 patients with advanced digestive neoplasm from Jan 2009 to Oct 2010 treated in Baoan district people′s hospital of Shenzhen.We randomLy assigned to receive either compound Kushen injection combined with FP chemotherapy（treatment group,n=70） or chemotherapy alone（control group,n=67） for 2-4 cycles（4 weeks in each cycle）.The adverse reactions,KPS scores（quality of life） and pain relief in the two groups were compared and analyzed.Results The incidences of reduction in side effect,showing significant differences between the two groups（P0.05）.The marked effective rate in KPS scores and rate of pain relief in treatment group were 74.29% and 73.64%,respectively,which were significantly higher than in the control group,showing significant differences between the two groups（P0.05）.Conclusion The addition of compound Kushen injection to chemotherapy significantly attenuated the toxic side effects of chemotherapy,increased patients＇ tolerance to chemotherapy and improved patients＇ quality of life,which is of benefits for patients with digestive neoplasm and it was worth clinical application.