| 复方苦参(岩舒)注射液联合顺铂治疗恶性胸腔积液的临床研究 |
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| 引用本文： | 陈运芳,李琦,向森,杨光华. 复方苦参(岩舒)注射液联合顺铂治疗恶性胸腔积液的临床研究[J]. 中国医院用药评价与分析, 2011, 0(4): 366-367 |
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| 作者姓名： | 陈运芳 李琦 向森 杨光华 |
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| 作者单位： | 驻马店市中心医院肿瘤科; |
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| 摘 要： | 目的:探讨复方苦参(岩舒)注射液联合顺铂治疗恶性胸腔积液的疗效。方法:将本院2002年12月—2008年12月168例恶性胸腔积液住院患者随机分为2组,均采用中心静脉导管胸腔留置持续负压吸引,放净胸水后化疗。试验组84例:顺铂40～60 mg+苦参60 mL胸腔灌注,5～7 d给予1次;对照组84例:顺铂40～60 mg胸腔灌注,5～7 d给予1次。结果:顺铂+苦参2药联合较单用顺铂疗效明显提高,不良反应轻(粒细胞减少发生率低),治疗组生活质量(KPS)评分试验组优于对照组,中位生存期和无疾病进展期较对照组延长。结论:岩舒注射液联合顺铂治疗恶性胸腔积液较单药顺铂治疗能提高恶性胸腔积液的控制率、提高生活质量、延长生存期;岩舒注射液联合化疗有保护骨髓功能的作用。
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| 关 键 词： | 复方苦参注射液 顺铂 恶性胸腔积液 |
Compound Kusheng Injection Combined with Cisplatin for Malignant Pleural Effusion:A Clinical Study |
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| CHEN Yun-fang,LI Qi,XIANG Sen,YANG Guang-hua. Compound Kusheng Injection Combined with Cisplatin for Malignant Pleural Effusion:A Clinical Study[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2011, 0(4): 366-367 |
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| Authors: | CHEN Yun-fang LI Qi XIANG Sen YANG Guang-hua |
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| Affiliation: | CHEN Yun-fang,LI Qi,XIANG Sen,YANG Guang-hua(Dept.of Oncology,Zhumadian Municipal Central Hospital,Zhumadian 463400,China) |
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| Abstract: | OBJECTIVE: To evaluate the efficacy of compound Kusheng injection combined with Cisplatin for malignant pleural effusion.METHODS: A total of 168 patients with malignant pleural effusion hospitalized in our hospital between Dec.2002 and Dec.2008 were randomized to receive either cisplatin at a dose of 40-60 mg plus Kushen at a dose of 60 mL vial thoracic perfusion once every 5-7 days(trial group,n = 84) or cisplatin at a dose of 40-60 mg vial thoracic perfusion once every 5-7 days(trial group,n = 84).Both gr... |
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| Keywords: | Compound Kushen injection Cisplatin Malignant pleural effusion |
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