利培酮口服液与氟哌啶醇治疗儿童抽动障碍的对照研究

目的:比较利培酮口服液与氟哌啶醇治疗儿童抽动障碍的疗效及不良反应。方法:对102例儿童抽动障碍分别给予利培酮口服液与氟哌啶醇治疗,其中利培酮口服液组51例,氟哌啶醇组51例。疗效评定采用耶鲁抽动症状严重程度量表(YGTSS),不良反应采用不良反应量表(TESS),观察8周。结果:利培酮口服液组显好率、好转率分别为58.82%、76.47%,氟哌啶醇组显好率、好转率分别为56.86%、72.55%,2组总有效率接近,氟哌啶醇组流涎、震颤、EKG异常多见。结论:利培酮口服液和氟哌啶醇同样能有效治疗儿童抽动障碍,利培酮口服液依从性较好。

Risperidone Oral Solution vs. Haloperidol in the Treatment of Childhood Tic Disorder

OBJECTIVE:To evaluate the efficacy and side effects of risperidone oral solution vs.haloperidol in the treatment of childhood Tic disorder.METHODS:102 cases of childhood Tic disorder were treated with either risperidone oral solution(n=51)or haloperidol(n=51).The two groups were followed for 8 weeks with efficacy evaluated using Yale Global Tie Severityb Scale(YGTSS)and side effects evaluated using TESS.RESULTS:The effective rate and improvement rate in patients receiving risperidone oral solution were 58.8...