| 多利培南的药理学特点与临床应用评价 |
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| 引用本文： | 郑仙香,侯国俊,林智敏.多利培南的药理学特点与临床应用评价[J].中国医院用药评价与分析,2011(3):195-197. |
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| 作者姓名： | 郑仙香 侯国俊 林智敏 |
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| 作者单位： | 南京军区福州总医院第一附属医院药械科; |
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| 摘 要： | 目的:概括多利培南的药理学特点,评价其临床应用。方法:收集国内外相关文献,从多利培南的作用机制、抗菌活性、耐药机制、药代动力学等方面进行分析、评价。结果与结论:多利培南是新型碳青霉烯类抗生素,具有较广的抗菌谱,对革兰阳性菌、革兰阴性菌和厌氧菌均有较强的抗菌作用。
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| 关 键 词： | 多利培南 抗菌活性 耐药机制 药代动力学 临床应用 |
Pharmacological Characteristics and Clinical Application of Doripenem |
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| ZHENG Xian-xiang,HOU Guo-jun,LIN Zhi-min.Pharmacological Characteristics and Clinical Application of Doripenem[J].Evaluation and Analysis of Drug-Use in Hospital of China,2011(3):195-197. |
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| Authors: | ZHENG Xian-xiang HOU Guo-jun LIN Zhi-min |
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| Institution: | ZHENG Xian-xiang,HOU Guo-jun,LIN Zhi-min(Dept. of Drug and Equipment,The First Affiliated Hospital of Fuzhou General Hospital of Nanjing Military Region,Putian 351100,China) |
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| Abstract: | OBJECTIVE:To summarize the pharmacological characteristics of doripenem and evaluate its clinicalapplication.METHODS:The pertinent literature both at home and abroad was collected for analysis and evaluation with regard to mechanism of action,antimicrobial activity,drug resistance mechanisms and pharmacokinetics etc.RESULTS & CONCLUSION:Doripenem is a new Carbapenems antibiotic with broad antibacterial spectrum potent antibacterial effects on gram positive bacteria,gram negative bacteria and anaerobic bacte... |
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| Keywords: | Doripenem Antibacterial activity Drug resistance mechanisms Pharmacokinetics Clinical application |
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