| 环磷酰胺、吗替麦考酚酯治疗难治性肾病综合征的药物经济学分析 |
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| 引用本文： | 吴晓玲,姚胜林. 环磷酰胺、吗替麦考酚酯治疗难治性肾病综合征的药物经济学分析[J]. 中国医院用药评价与分析, 2011, 0(3): 252-254 |
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| 作者姓名： | 吴晓玲 姚胜林 |
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| 作者单位： | 广东省中西医结合医院; |
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| 摘 要： | 目的:主要比较环磷酰胺、吗替麦考酚酯治疗难治性肾病综合征的用药方案的疗效,评价分析2种方案的成本-效果。方法:将36例患者按随机双盲法分成2组,通过对A组(泼尼松龙+环磷酰胺)、B组[泼尼松龙+吗替麦考酚酯分散片(赛可平)]2种方案治疗难治性肾病综合征的疗效观察,运用药物经济学方法分析其成本-效果。结果:A组完全缓解39.3%、部分缓解19.5%、总有效率58.8%,成本/效果比为17.19%;B组完全缓解40.1%、部分缓解20.2%、总有效率60.3%,成本/效果比为59.28%,经过检验分析,A组无论药物成本、总成本/效果比均低于B组。结论:A组方案在治疗难治性肾病综合征方面具有成本、效果优势。
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| 关 键 词： | 难治性肾病综合征 环磷酰胺 吗替麦考酚酯 药物经济学分析 |
Cyclophamide vs. Mycophenolate Mofetil in the Treatment of Refractory Nephrotic Syndrome:Pharmacoeconomic Analysis |
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| WU Xiao-ling,YAO Sheng-lin. Cyclophamide vs. Mycophenolate Mofetil in the Treatment of Refractory Nephrotic Syndrome:Pharmacoeconomic Analysis[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2011, 0(3): 252-254 |
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| Authors: | WU Xiao-ling YAO Sheng-lin |
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| Affiliation: | WU Xiao-ling,YAO Sheng-lin(Guangdong Hospital of Integrated Traditional and Western Medicine,Foshan 528200,China) |
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| Abstract: | OBJECTIVE:To evaluate the efficacy of cyclophosphamide vs.mycophenolate mofetil in the treatment of refractory nephrotic syndrome and evaluate and analyze the cost-effectiveness of the two therapeutic schemes.METHODS:By a randomized double blind method,a total of 36 patients with refractory nephrotic syndrome were randomized to group A(Prednisolone + cyclophosphamide) or group B(Prednisolone + Mycophenolate mofetil dispersible tablets).The curative efficacy in the two groups was observed and the cost-effect... |
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| Keywords: | Refractory nephrotic syndrome Cyclophosphamide Mycophenolate mofetil Pharmacoeconomic analysis |
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