Effect of chlorpromazine on glucose and tolbutamide-stimulated insulin release in the adrenalectomized rat |
| |
| Authors: | A S Susten J H Mennear T S Miya |
| |
| Institution: | Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, Lafayette, Indiana 47907 USA |
| |
| Abstract: | The influence of chlorpromazine pretreatment on the insulin response to glucose and tolbutamide was investigated in adrenalectomized rats. Chlorpromazine pretreatment (10 mg/kg, ip) reduced the capacity of the animals to secrete insulin in response to intravenously administered glucose and tolbutamide. Furthermore, it appeared that in the adrenalectomized rat, the insulin response to tolbutamide was not transient but multiphasic and prolonged. The data suggest that the reduction in glucose tolerance in rats following chlorpromazine pretreatment may be due, in part, to a reduced beta cell responsiveness. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
