Comparison of adapalene 0·1% solution and tretinoin 0·025% gel in the topical treatment of acne vulgaris |
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| Authors: | Ellis Millikan Smith Chalker Swinyer Katz Berger Mills Jr Baker Verschoore & Loesche |
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| Institution: | Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI; Department of Dermatology, Tulane University Medical Center, New Orleans, LA; Department of Dermatology, University of Texas Medical Branch, Galveston, TX; Department of Dermatology, Medical College of Georgia, August, GA; Private Practice, Salt Lake City, UT; Private Practice, Fridley, MN; Hill Top Research, UMDNJ, Robert Wood Johnson Medical School, East Brunswick, NJ; Hill Top Research, UMDNJ, Robert Wood Johnson Medical School, East Brunswick, NJ; Galderma Laboratories, Inc., Fort Worth, TX; Laboratoires Galderma, Levallois-Perret, France; Galderma R&D, Sophia Antipolis, France |
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| Abstract: | A multicentre study was conducted to compare clinical safety and efficacy of adapalene 0·1% solution and tretinoin 0·025% gel, both topical treatments for acne, in a once-daily dosage regimen for 12 weeks. A total of 297 patients were enrolled by eight investigators in this randomized, investigator-masked study in a parallel group design. An open label period using adapalene followed this study to assess the long-term safety of adapalene solution.
Adapalene and tretinoin proved to be clinically and statistically effective in treating acne by reducing inflammatory (47% and 50%, respectively) and non-inflammatory lesions (57% and 54%) as compared to baseline. When comparing patients who had 75% or greater improvement in open comedones, adapalene was shown to be significantly more effective than tretinoin. No serious adverse event was reported during this study, including during the long-term period. The reactions that occurred were similar between treatments, i.e. burning, pruritus, scaling, dryness and erythema. |
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