| 近红外光谱法快速测定右旋糖酐40葡萄糖注射液的含量 |
| |
| 引用本文： | 吴少平,李小安,刘海静,郭欢迎.近红外光谱法快速测定右旋糖酐40葡萄糖注射液的含量[J].西北药学杂志,2011,26(5):344-347. |
| |
| 作者姓名： | 吴少平 李小安 刘海静 郭欢迎 |
| |
| 作者单位： | 1. 陕西省食品药品检验所,陕西西安,710061
2. 陕西省食品药品检验所,陕西西安710061;陕西中医学院,陕西咸阳712046 |
| |
| 摘 要： | 目的运用近红外透反射光谱分析技术和化学计量学方法对右旋糖酐40葡萄糖注射液进行无损、快速定量分析。方法以在全国范围内不同企业生产的右旋糖酐40葡萄糖注射液及实验室自制不同质量浓度的样品为分析对象,用光纤探头和液体测样附件测定近红外光谱,用偏最小二乘法(PLS)建立右旋糖酐40和葡萄糖定量模型。结果所建模型具有良好的预测能力,测定验证集中样品的含量,葡萄糖外部验证均方差(RMSEP)为0.749,右旋糖酐40外部验证均方差(RMSEP)为0.74;与药典标准方法相比,NIR法测定葡萄糖平均预测偏差为0.62,平均相对偏差为1.87%,右旋糖酐40平均预测偏差为0.59,平均相对偏差为1.53%。结论该方法快速无损,结果准确,可用于该制剂快速同时检测分析。
|
| 关 键 词： | 右旋糖酐40葡萄糖注射液 近红外光谱 偏最小二乘法 |
Development of a near IR method for rapid determination of Dextran 40 Glucose Injection |
| |
| WU Shaoping,LI Xiaoan,LIU Haijing,GUO Huanying.Development of a near IR method for rapid determination of Dextran 40 Glucose Injection[J].Northwest Pharmaceutical Journal,2011,26(5):344-347. |
| |
| Authors: | WU Shaoping LI Xiaoan LIU Haijing GUO Huanying |
| |
| Institution: | WU Shaoping1,LI Xiaoan1,2,LIU Haijing1*,GUO Huanying1(1.Shaanxi Institute for Food and Drug Control,Shaanxi Xi'an 710061,China,2.Shaanxi College of Traditional Chinese Medicine,Shaanxi Xianyang 712046,China) |
| |
| Abstract: | Objective To develop a method for rapid,non-destroyed determination of Dextran 40 Glucose Injection by near infrared spectroscopy technology and chemometrics.Methods The analytic samples from different pharmaceutical factories in China and laboratory-made samples were determined by a fiber optic probe and liquid-like attachment.The partial least square(PLS) was applied to establish the model.Results The model had a good performance for prediction.The root mean square error of prediction(RMSEP) of glucose wa... |
| |
| Keywords: | Dextran 40 Glucose Injection near infrared spectroscopy partial least square |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
