EGFR敏感突变阴性非小细胞肺癌脑转移患者临床特征

除少见的间变性淋巴瘤激酶(anaplastic lymphoma kinase, ALK)及原癌基因-1受体酪氨酸激酶(c-ros oncogene 1-receptor tyrosine kinase, ROS1)阳性敏感融合外,非表皮生长因子受体(epidermal growth factor receptor,EGFR)敏感突变的非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移患者目前无有效的全身治疗药物,整体预后较差。由于传统药物血脑屏障透过率低,脑转移的局部治疗尤其是放疗具有非常重要作用。为了更好地认识EGFR突变阴性NSCLC脑实质转移的特点,本文从脑转移的发病率、发病时间、发病部位、病灶数目及大小、发病症状、治疗疗效和病情演变等方面综述了EGFR突变阴性NSCLC脑实质转移的临床特征以及治疗,为脑实质转移局部治疗的介入时机以及局部治疗技术选择提供参考。

Clinical Features of EGFR Mutation Negative in Patients with Non-small Cell Lung Cancer and Brain Metastases

In addition to rare incidence of anaplastic lymphoma kinase(ALK) and c-ros oncogene 1 receptor kinase(ROS1) positive patients, patients with brain metastases of non-small cell lung cancer(NSCLC) without epidermal growth factor receptor(EGFR) sensitive mutation have no effective systemic therapy at present, and the overall prognosis is poor. Since the low blood-brain barrier permeability of chemotherapy drugs, the local treatment plays an important role in brain metastases. To understand the clinical characteristics and treatment of brain parenchymal metastases in patients with NSCLC and EGFR mutation negative, we reviewed the incidence, onset time, site, numbers, size, symptom, therapeutic effect and disease evolution in them, which can provide reference for interventional timing and local treatment technology selection of local treatment for brain parenchymal metastases.