布地奈德治疗儿童支气管哮喘的时间长短对生长发育影响的研究

目的探讨吸入性布地奈德治疗儿童支气管哮喘的时间长短对疗效及生长发育的影响性。方法选取2019年6月至2020年6月于台州市肿瘤医院收治的支气管哮喘患儿60例为研究对象,按照随机数字表法分为观察组30例与对照组30例。在常规治疗基础上,对照组给予3个月的布地奈德气雾剂治疗,观察组给予6个月的布地奈德气雾剂治疗。比较两组的总体疗效、肺功能变化、日间和夜间症状积分、血清胰岛素样生长因子-1(IGF-1)水平变化,及患儿1年后身高增长率和体质量指数(BMI)变化。结果观察组总有效率显著高于对照组,差异具有统计学意义(χ²=3.909,P<0.05);观察组与对照组治疗后用力肺活量(FVC)和第1秒用力呼气容积占预计值百分比(FEV1%)均显著高于治疗前(t值分别为17.384、19.310、8.287、9.989,均P<0.05),治疗后观察组FVC和FEV1%均显著高于对照组(t值分别为9.597、9.430,均P<0.05);观察组与对照组治疗后日间和夜间症状积分均显著低于治疗前(t值分别为20.002、20.410、11.209、10.714,均P<0.05),治疗后观察组日间和夜间症状积分均显著低于对照组(t值分别为10.824、10.237,均P<0.05);观察组与对照组治疗后血清IGF-1水平较治疗前比较差异无统计学意义,两组治疗后血清IGF-1水平比较差异也无统计学意义(均P>0.05);两组患儿1年后身高增长率和BMI比较差异无统计学意义(均P>0.05)。结论布地奈德维持6个月治疗支气管哮喘临床疗效显著,且可显著改善肺部功能,但对患儿生长发育影响不大,值得临床推广。

Effect of budesonide on the growth and development of children with bronchial asthma

Objective To investigate the effect of inhaled budesonide on the efficacy and growth and development of children with bronchial asthma.Methods The 60 children with bronchial asthma admitted to Taizhou Cancer Hospital from June 2019 to June 2020 were selected as the research objects,and they were divided into observation group(30 cases)and control group(30 cases)according to the random number table.Basis on conventional treatment,the control group was given budesonide aerosol for 3 months,and the observation group was given budesonide aerosol for 6 months.The overall efficacy,changes in pulmonary function,daytime and night symptom score,serum insulin-like growth factor-1(IGF-1)level,height growth rate and body mass index(BMI)changes after 1 year of two groups were compared.Results The total effective rate(100.00%)of observation group was significantly higher than control group(83.33%),and the difference was statistically significant(χ²=3.909,P<0.05).After treatment,the forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1%)of the observation group and the control group were significantly higher than those before treatment(t=17.384,19.310,8.287 and 9.989,respectively,all P<0.05).After treatment,the FVC and FEV1%of observation group were significantly higher than those of control group(t=9.597 and 9.430,respectively,both P<0.05).After treatment,the day and night symptom scores of the observation group and the control group were significantly lower than those of before treatment(t=20.002,20.410,11.209 and 10.714,respectively,all P<0.05).After treatment,the day and night symptom scores of the observation group were significantly lower than those of the control group(t=10.824 and 10.237,respectively,both P<0.05).There was no significant difference in serum IGF-1 level between the observation group and the control group of before treatment and after treatment(all P>0.05).There was no significant difference in height growth rate and BMI between the two groups after 1 year(all P>0.05).Conclusion Budesonide maintenance for 6 months in the treatment of bronchial asthma clinical curative effect is obvious,and can significantly improve lung function,but has little impact on the growth and development of children,it is worthy of clinical promotion.