Determinants of plasma triglyceride levels in a multiethnic working class Caribbean population: Effect of ethnicity,diet and obesity |
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Authors: | Dinesh Dan Ramdath Shamjeet Singh Debbie G. Hilaire B. Shivananda Nayak |
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Affiliation: | Biochemistry Unit, Department of Pre-clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago |
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Abstract: | AimsObjective of the study is to identify the predictors of plasma triglycerides.Materials and methodsA stratified random sample of university staff categories underwent measurements of anthropometry, blood pressure, and fasting blood glucose, insulin, lipids, CRP and homocysteine. Dietary intakes were assessed using duplicate 24 h recalls. HOMA-IR was calculated. Stepwise, multivariate regression analysis was performed with TAG as the dependent variable.ResultsThe sample (n = 251) was 55% females with a mean age of 44.9 ± 9.7 years. African ancestry comprised 43%, followed South Asian 30% and mixed ethnicity 27%. Prevalence of obesity was 19.4%, insulin resistance 22.7% and metabolic syndrome 21.6%. Males had significantly higher (p < 0.01) triglycerides and VLDL and lower HDL than females. Africans had significantly lower triglycerides and cholesterol than South Asians and Mix. Triglycerides were significantly (p < 0.01) correlated with glucose, cholesterol, insulin, CRP, systolic, diastolic blood pressure, WC, BMI, age and components of MS. Glucose, cholesterol, insulin and total energy intake predicted TAG, to varying extents, in all participants (R2 = 45.1%), males (R2 = 40.3%), females (R2 = 56.0%), Africans (R2 = 35.0%), TSA (R2 = 31.5%) and mix (R2 = 51.0%).ConclusionsAfricans have lower triglycerides and cholesterol than South Asians and mix. Major predictors of triglycerides were fasting glucose and cholesterol independent of gender and ethnicity. |
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Keywords: | Triglyceride Anthropometry Ethnicity Lipoproteins High density lipoproteins Very low density lipoproteins |
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