| 磷脂酰肌醇-3激酶/蛋白激酶B信号通路在肝细胞癌和靶向药耐药中作用研究进展 |
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| 引用本文： | 李昊,胡宇,唐强,张宏伟,薛飞.磷脂酰肌醇-3激酶/蛋白激酶B信号通路在肝细胞癌和靶向药耐药中作用研究进展[J].中华实用诊断与治疗杂志,2021(2). |
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| 作者姓名： | 李昊 胡宇 唐强 张宏伟 薛飞 |
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| 作者单位： | 河南大学人民医院河南省人民医院肝胆外科 |
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| 基金项目： | 国家自然科学基金(81273260);河南省自然科学基金(182300410298);河南省科技攻关项目(201702190)。 |
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| 摘 要： | 磷脂酰肌醇-3-激酶/蛋白激酶B信号通路是影响肿瘤细胞增殖、凋亡、侵袭转移及化疗耐药的重要信号转导通路。肝细胞癌中存在磷脂酰肌醇-3-激酶/蛋白激酶B信号通路的传导异常。本文就磷脂酰肌醇-3-激酶/蛋白激酶B信号通路的功能、激活途径、在肝细胞癌进展及其对肝细胞癌靶向药耐药中作用的研究进展作一综述。
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| 关 键 词： | 磷脂酰肌醇-3-激酶/蛋白激酶B 信号传导 肝癌 靶向治疗 |
Roles of PI3K/Akt signaling pathway in hepatocellular carcinoma and targeted drug resistance |
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| LI Hao,HU Yu,TANG Qiang,ZHANG Hong-wei,XUE Fei.Roles of PI3K/Akt signaling pathway in hepatocellular carcinoma and targeted drug resistance[J].Journal of Chinese Practical Diagnosis and Therapy,2021(2). |
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| Authors: | LI Hao HU Yu TANG Qiang ZHANG Hong-wei XUE Fei |
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| Institution: | (Department of Hepatobiliary,Henan University People's Hospital,Henan Provincial People's Hospital,Zhengzhou,Henan 450003,China) |
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| Abstract: | Hosphatidylinositol-3-kinases-protein-serine-threoninekinase(PI3 K/Akt) signaling pathway is an important signal transduction pathway that affects tumor cell proliferation, apoptosis, invasion and metastasis, as well as chemotherapy resistance. The conduction of PI3 K/AKt signaling pathway is abnormal in hepatocellular carcinoma. This paper reviews the research progress of PI3 K/Akt signaling pathway in the function, activation pathways, advance in hepatocellular carcinoma and resistance to targeted drugs for hepatocellular carcinoma. |
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| Keywords: | hosphatidylinositol-3-kinases-protein-serine-threoninekinase signal transduction hepatocellular carcinoma targeted therapy |
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