糖尿病视网膜病变中医证型分布频率的Meta分析

目的 系统客观定量地分析糖尿病视网膜病变中医证型分布频率,为其先验概率分布情况提供循证医学依据.方法 通过中国知网、维普、万方、CBM、PubMed、Embase等数据库检索关于糖尿病视网膜病变中医证型的相关文献,检索时限设定为建库至2020年6月4日,采用双人双机独立检索并交叉核对,并采用Rev Man 5.3软件进...

A Meta-analysis of the Distribution Frequency of TCM Syndromes in Diabetic Retinopathy

Objective To systematically,objectively and quantitatively evaluate the distribution of TCM syndrome types of diabetic retinopathy,and provide evidence-based medicine basis for its prior probability distribution.Methods Such databases as CNKI,VIP,Wanfang academic journal full-text database,CBM,PubMed,EMBASE were searched from the establishment of the database to June 4,2020.Two researchers independently screened literatures according to the inclusion and exclusion criteria and crosschecked it.And then meta-analysis was performed by using Rev Man 5.3 software.Results 25 literatures involving 3350 cases were included.The results of meta-analysis showed that the distribution frequency of qi and Yin deficiency,blood stasis syndrome was 0.45[95%CI(0.33,0.58)];the distribution frequency of qi-Yin deficiency syndrome was 0.44[95%CI(0.35,0.53)];the distribution frequency of blood stasis syndrome was 0.31[95%CI(0.17,0.49)];the distribution frequency of dampness and turbidity syndrome was 0.24[95%CI(0.01,0.47)];Yin and Jin deficiency and dry heat endogenous syndrome was 0.23[95%CI(0.04,0.42)];the distribution frequency of Yin-Yang deficiency syndrome was 0.19[95%CI(0.15,0.23)];the distribution frequency of liver-kidney deficiency syndrome was 0.17[95%CI(0.11,0.25)];the distribution frequency of syndrome of deficiency of Yin and Yang,blood stasis and phlegm coagulation was 0.12[95%CI(0.07,0.19)];the distribution frequency of syndrome of internal heat of yin deficiency was 0.05[95%CI(0.01,0.20)].The results of subgroup analysis showed that there was statistical significance in the distribution of qi-Yin deficiency syndrome in different regions(P<0.05).There were statistical significance in the distribution of liver-kidney deficiency syndrome and Yin-Yang deficiency syndrome in different course of disease(P>0.05).Conclusion Deficiency of qi and Yin,blood stasis syndrome was the most frequent TCM syndrome types of diabetic retinopathy.There is regional difference in the distribution of qi-Yin deficiency syndrome.The distribution frequency of liver-kidney deficiency syndrome and Yin-Yang deficiency syndrome are related to the course of the disease.