噻托溴铵联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的临床效果

目的 观察噻托溴铵联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的临床效果.方法 选取2019年1-10月江苏省张家港市第一人民医院收治的慢性阻塞性肺疾病患者58例,采用随机数字表法分为观察组和对照组各29例.对照组接受噻托溴铵治疗,观察组接受噻托溴铵联合N-乙酰半胱氨酸治疗,2组均开展呼吸训练.比较2组临床疗效,治疗前后血...

Clinical effect of tiotropium bromide combined with N-acetylcysteine in the treatment of chronic obstructive pulmonary disease

Objective To observe the clinical effect of tiotropium bromide combined with N-acetylcysteine in the treatment of chronic obstructive pulmonary disease.Methods Fifty-eight patients with chronic obstructive pulmonary disease admitted to Zhangjiagang First People’s Hospital,Jiangsu Province from January to October 2019 were selected.They were divided into observation group and control group by random number table method,each of 29 cases.The control group received tiotropium bromide treatment,the observation group received tiotropium bromide combined with N-acetylcysteine treatment,and both groups received respiratory training.Compared the clinical efficacy,before and after treatment arterial blood oxygen partial pressure(PaO₂),blood oxygen saturation(SpO₂),arterial carbon dioxide partial pressure(PaCO₂),1 s forced expiratory volume(FEV₁),FEV₁/forced vital capacity(FVC),FEV₁as a percentage of the predicted value,adverse reactions between the two groups.Results After treatment,two groups of PaO₂,SpO₂levels were elevated/PaCO₂level decreased,and the observation group improved amplitude was greater than the control group(P<0.01).After treatment,two groups of FEV₁,FEV₁/FVC,FEV₁accounts for the percentage of the estimated value were increased,and the observation group was higher than the control group(P<0.05).Observation group the incidence of adverse reactions to the total was 17.24%,control group in the incidence of adverse reactions to the total was 13.79%,there was no statistically significant difference comparing between the two groups(χ²=0.132,P=0.717).Conclusion Tiotropium bromide combined with N-acetylcysteine in the treatment of chronic obstructive pulmonary disease can significantly improve the blood gas status and lung function,and the treatment is safe and worthy of promotion.