超微肿痛贴联合独活寄生汤治疗膝骨关节炎的疗效观察

目的 观察超微肿痛贴联合独活寄生汤治疗膝骨关节炎(knee osteoarthritis,KOA)的临床疗效及其对骨代谢标志物的影响.方法 选取2019年4月至2019年12月湖南省中医药研究院附属医院骨伤科住院部的70例KOA患者,随机均等分为观察组与对照组,各35例,观察组予超微肿痛贴外敷联合独活寄生汤内服治疗,对...

Observation of Curative Effect on Knee Osteoarthritis Treated by Ultramicro Swelling and Pain Paste Combined with Duhuo Jisheng Decoction

Objective To observe the clinical effect and effect on bone metabolism markers on knee osteoarthritis(KOA)treated by ultramicro swelling and pain paste combined with Duhuo Jisheng Decoction.Methods 70 patients with KOA were selected from the department of orthopedics and traumatology of Hunan Academy of Traditional Chinese Medicine Affiliated Hospital from April 2019 to December 2019,and randomly divided into the observation group and the control group,35 cases in each group.The observation group was treated with ultramicro swelling and pain paste combined with internal administration of Duhuo Jisheng Decoction,while the control group was treated with internal administration of Duhuo Jisheng Decoction.Both groups were treated with 14 days as a course of treatment,and the efficacy was evaluated after one course of treatment.The Western Ontario and McMaster Universities osteoarthritis index(WOMAC)score was used to evaluate the pain,stiffness and functional activity of knee before and after treatment,and the changes of bone metabolic markers[bone gla protein(BGP),osteoprotegerin(OPG)and bone specific alkaline phosphatase(BALP)]were evaluated.Results In the observation group,33 cases were effective and 2 cases were ineffective,the effective rate was 94.29%.In the control group,26 cases were effective and 9 cases were ineffective,with an effective rate of 74.29%(P<0.05).After treatment,compared with the control group,WOMAC score in the observation group were decreased(P<0.05),and the levels of BGP,OPG and BALP in bone metabolism were significantly increased(P<0.05).Conclusion External application of ultramicro swelling and pain paste combined with Duhuo Jisheng Decoction can effectively improve the physiological function,pain and stiffness of patients with KOA.The possible mechanism is to protect the function of cartilage by promoting bone metabolism,thus slowing down the process of KOA,which is worthy of clinical promotion and application.