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Oral leiomyomatous hamartoma associated with upper lip midline malformation: Case report and review of the literature
Authors:Saulo Gabriel Moreira Falci  Ana Terezinha Marques Mesquita  Mário José Romañach  Oslei Paes de Almeida  Cássio Roberto Rocha dos Santos
Affiliation:1. Department of Oral Diagnosis and Oral Surgery, Diamantina Dental School, Federal University of Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil;2. Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil;3. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil;1. Warwick Dentistry, Warwick Medical School, University of Warwick, Coventry, UK;2. Children''s Hospital Los Angeles, Los Angeles, CA, USA;3. Plastic and Reconstructive Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA;4. Department of Pediatrics, Children''s Hospital Los Angeles, Los Angeles, CA, USA;5. Division of Plastic and Maxillofacial Surgery, Children’s Hospital Los Angeles, Los Angeles, CA, USA;1. Department of Neurosurgery, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium;2. Department of Paediatric Neurology, University Hospitals Leuven, Leuven, Belgium;3. Department of Pathology, University Hospitals Leuven, Leuven, Belgium;4. Department of Radiology, University Hospitals Leuven, Leuven, Belgium;1. Key Laboratory of Oral Pathology, School and Hospital of Stomatology, Peking University, Beijing, China;2. Department of Oral and Maxillofacial Radiology, School and Hospital of Stomatology, Peking University, Beijing, China;1. Attending Surgeon, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;2. Resident, Department of Endodontics, School of Stomatology, Shandong University, Jinan, China;3. Resident, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;4. Attending Surgeon, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;6. Attending Surgeon, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;5. Professor and Chairman, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China;1. Department of Cranio-Maxillo-Facial Surgery of the pediatric hospital, hôpital Femme-Mère-Enfant, 59, boulevard Pinel, 69677 Bron, France;2. Université Claude-Bernard Lyon 1, 43, boulevard du 11 Novembre 1918, 69100 Villeurbanne, France;3. INSERM, National Institute of Health and Medical Research, Unit 1032, 151, Cours Albert-Thomas, 69424 Lyon cedex 03, France
Abstract:A 3-month-old male patient presented an upper lip malformation associated to a polypoid nodule in the maxillary anterior alveolar ridge. Microscopically, the nodule was predominantly composed by a non-encapsulated smooth muscle proliferation intermingled by numerous blood vessels of varied sizes and scattered small nerve fibers. The smooth muscle tissue was positive for desmin and smooth muscle actin, while endothelial cells were highlighted by CD34 staining. The final diagnosis was of an oral leiomyomatous hamartoma associated with upper lip malformation. After surgical treatment, no recurrence has been observed after 2 years of follow-up.
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