Liver preservation prior to transplantation: Past,present, and future |
| |
Authors: | Marcio F Chedid Marcelo A Pinto Jose Felipe G Juchem Tomaz J M Grezzana-Filho Cleber R P Kruel |
| |
Institution: | Marcio F Chedid, Marcelo A Pinto, Jose Felipe G Juchem, Tomaz J M Grezzana-Filho, Cleber R P Kruel, Liver Transplant and Hepatobiliary Surgery Unit, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90035-903, Brazil |
| |
Abstract: | Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's group reported the first successful LT using the University of Wisconsin preservation solution(UW).Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution.Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation. |
| |
Keywords: | Liver transplantation University of Wisconsin preservation solution Institute Georges Lopez preservation solution Celsior preservation solution Histidine-tryptophan-ketoglutarate preservation solution Dymamic preservation Normothermic ischemia Normothermic preservation Hypotermic machine preservation Static cold prreservation |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《World journal of gastrointestinal surgery》浏览原始摘要信息 |
|