口服何首乌制剂用药前后肝功能变化分析

目的 研究临床常规使用含何首乌汤剂及中成药患者用药前后肝功能指标变化,分析其临床应用的肝损伤风险.方法 收集35例临床使用含何首乌汤剂或中成药患者的一般资料,并对患者用药前后谷丙转氨酶(ALT)、门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、谷氨酰转肽酶(GGT)、总胆红素(TBIL)、直接胆红素(DBIL)和间...

Changes of Liver Function in 35 Patients Orally Taking Polygoin Multiflori Radix Preparations

Objective To analyze the post-treatment changes of liver function in patients taking a conventional dosage of decoction and Chinese patent medicine containing Polygoni Multiflori Radix(PMR),and to determine the risk of liver injury in clinical application.Methods The clinical data on 35 cases who used decoction and Chinese patent medicine containing PMR was collected.Their liver function indexes,such as alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),γ-glutamyl transpeptadase(GGT),total bilirubin(TBIL),direct bilirubin(DBIL)and indirect bilirubin(IBIL),were detected.The patients were divided into two groups according to the normality of their liver function indexes before treatment and the incidence of liver injury after treatment was analyzed.Results There was no significant difference in levels of AST,ALP,GGT,TBIL,DBIL or IBIL after treatment(P>0.05)in patients who had normal liver function before treatment,but there was significant difference in ALT(P<0.05)that was in the normal range.Among patients who had abnormal liver function before treatment,there was also no significant difference in levels of ALP,GGT,TBIL or IBIL after treatment(P>0.05),but some of their liver function indexes decreased after treatment.Conclusion Taking orally a conventional dosage of decoction and Chinese patent medicine containing PMR is relatively safe and has lower clinical risk of liver injury.