CYP2C9和VKORC1基因多态性对华法林抗凝疗效的影响

目的:分析探讨CYP2C9和VKORC1基因多态性对华法林抗凝疗效的影响,为进一步指导临床精准合理化用药提供参考.方法:通过医院电子病历系统收集昆明市某三甲医院2019年1月至2020年9月住院期间患者服用华法林抗凝治疗的184例临床信息,并根据是否进行CYP2C9(1075A>C)、VKORC1(1639 G>A)基...

Influence of CYP2C9 and VKORC1 Gene Polymorphisms on the Anticoagulant Efficacy of Warfarin

Objective:To analyze and explore the effect of CYP2C9 and VKORC1 gene polymorphism on warfarin anticoagulant effect,and to provide reference for further guidance of clinical accurate and rational drug use.Methods:The clinical information of 184 patients who took warfarin anticoagulant therapy from January 2019 to September 2020 in a third class hospital in Kunming was collected through the hospital electronic medical record system,and based on whether to CYP2C9(1075A>C)、VKORC1(1639G>A)gene detection was divided into individualized medication group(test group)and traditional administration group(control group),and comparative analysis of relevant clinical indicators of the two groups of patients.Results:Compared with the control group,the number of cases with international normalized ratio(INR)>4 and the number of vitamin K1 use cases in the test group were significantly reduced(P<0.05).However,there was no significant difference in the number of warfarin-related bleeding cases,the average number of INR tests,and the average length of stay between the two groups(P>0.05).Conclusion:The individualized medication of warfarin according to CYP2C9 and VKORC1 gene detection can improve the anticoagulant effect of patients,reduce the risk of adverse reactions,and ensure the effectiveness and safety of warfarin therapy.