奥氮平临床不良反应文献分析

目的探讨奥氮平引起不良反应的规律及特点,为临床安全合理用药提供依据。方法检索中国知网、万方数据和维普网从建库至2019年9月30日有关奥氮平引发不良反应的文献报道进行回顾性分析。结果共筛选出82篇有效文献,104例病例,男女比例为1∶1.08,年龄集中在18~44岁(51例,49.04%)。奥氮平引起不良反应多发生在用药时间2~7 d(33例,31.73%);累及的系统-器官以中枢及外周神经系统(56例,29.79%)为主,表现为迟发型肌张力障碍、不安腿综合征等症状,其次为代谢和营养障碍(33例,17.55%)。结论临床应高度重视奥氮平的不良反应,加强用药监护,确保用药安全。

Literature Analysis of Adverse Drug Reactions Induced by Olanzapine

Objective To investigate the regularity and characteristics of adverse drug reactions(ADR)induced by olanzapine so as to provide reference for safe and rational use of drugs.Methods CNKI,Wanfang and VIP databases were searched for literature related to ADR induced by olanzapine.The included articles were analyzed retrospectively.Results A total of 82 articles involving 104 patients were retrieved.The ratio of males to females was 1∶1.08,and the age of most of these patients ranged from 18 to 44(51 cases,49.04%).Thirty-three of these patients(31.73%)had adverse reactions within 2 to 7 days of medication.The dominating systems or organs involved were the central nervous system(56 cases,29.79%)as manifested by tardive dystonia and restless leg syndrome,followed by metabolic and nutritional disorders(33 cases,17.55%).Conclusion Adverse reactions induced by olanzapine are worthy of attention.Drug use monitoring has to be strengthened to ensure drug safety.