| Flow cytometry in lymphoma diagnosis and prognosis: useful? |
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| 引用本文： | Stetler-Stevenson M. Flow cytometry in lymphoma diagnosis and prognosis: useful?[J]. Best Practice & Research: Clinical Haematology, 2003, 16(4): 583-597. DOI: 10.1016/S1521-6926(03)00068-9 |
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| 作者姓名： | Stetler-Stevenson M |
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| 摘 要： |
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| 收稿时间： | 2003-05-01 |
Flow cytometry in lymphoma diagnosis and prognosis: useful? |
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| Stetler-Stevenson Maryalice. Flow cytometry in lymphoma diagnosis and prognosis: useful?[J]. Best Practice & Research: Clinical Haematology, 2003, 16(4): 583-597. DOI: 10.1016/S1521-6926(03)00068-9 |
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| Authors: | Stetler-Stevenson Maryalice |
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| Affiliation: | Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 2N-108, Mail Stop 1500, Bethesda, MD 20892, USA. stetler@mail.nih.gov |
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| Abstract: | Flow cytometry has become an important tool in the diagnosis of mature lymphoid neoplasms and the determination of prognosis in selected cases. The advantages of flow cytometry are based largely on its ability to analyse, rapidly and simultaneously, multiple cell properties in a quantitative manner. Flow cytometric immunophenotyping is useful in diagnosing lymphoma under the WHO classification system, where lymphoid neoplasms are separated into distinct clinical entities based upon morphology, immunophenotype, genetic abnormalities and clinical features. Flow cytometry can quantify the expression of proteins associated with a good or poor prognosis, detect multidrug resistance, and measure cell proliferation, making it useful in measuring prognostic indicators in lymphoid neoplasia. The unique attributes of flow cytometry therefore make it a valuable technique in the diagnosis and classification of lymphomas as well as the assessment of prognostic markers in lymphoma patients. |
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| Keywords: | flow cytometry lymphoma prognosis immunophenotype |
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