大鼠Fyn缺损对神经发生和精子形成的共同点

以往认为 :脑和睾丸之间的胚胎发生、发育几乎没有共同点 ,神经发生和精子形成是毫无关系的两个系统。最近在帕金森氏病的研究中发现 ,神经元和睾丸支持细胞之间有许多共同之处 ,幼稚的神经元和放射状的神经胶质细胞的关系与生精细胞和支持细胞之间的关系非常相似。酪氨酸激酶Fyn属于Src家族成员 ,早期发现该基因fyn存在于鼠胚胎期中枢神经系统内 ,与神经细胞的发生、分化有关。近年来发现fyn也存在鼠的睾丸中。研究证明 :Fyn蛋白存在于支持细胞的细胞骨架 ,Fyn缺损可导致生精小管形成延缓 ,并出现细胞变性。另外 ,在生精小管中也发现了 ,维持神经细胞分化、生长、生存的神经营养因子的受体。

Common Effect of Fyn Deficiency to Neurogenesis and Spermatogenesis in Mice

In the past, it was thought that there were n o common in embryonic development between brain and testis, and it seems that ne urogenesis and spermatogenesis are two separating systems. Recently, scientists have found that there are some relations between neuron and sustentacular cell i n the Parkinson disease, which shows that the relationship between naive neuron and radiative neuroglial cell is similar to that between spermatogenital cell an d sustentacular cell. Fyn is one of the tyrosine protein kinase (TPK) in the Sr c family protein found in brain and testis and is detected in the central nervou s system of embryonic mice and in the skeleton of sustentacular cell, and has an effect on neurogenesis. The lack of Fyn in testis can lead to delayed formatio n of seminiferous tubule and degeneration of cells. In addition, the receptors o f neurotrophic factors which have an effect on neurogenesis also existed in the seminiferous tubule.